Journal of Advanced Periodontology & Implant Dentistry

Donor-Derived Dentin Matches Xenograft in Sinus Lift

Aghaziarati F, Chitsazi MT, Roshangar L

Source study: Effect of allogenic demineralized dentin matrix vs. xenograft in maxillary sinus floor augmentation: A randomized split-mouth study. — Journal of Advanced Periodontology & Implant Dentistry

In brief

  • Randomized split-mouth trial (n=9, bilateral sinus augmentation) comparing allogenic demineralized dentin matrix (ADDM) vs xenograft
  • No significant difference in bone height gain (9.34 vs 9.12 mm) or density gain (618.65 vs 540.87 HU) at 6 months
  • Histology: viable new bone in both groups, ADDM with higher collagen fiber density and vascularization
  • Small sample (n=9) — promising findings that need confirmation in larger cohorts

Clinical question: how does allogenic demineralized dentin matrix (ADDM) — a donor-derived bone graft substitute — compare with xenograft for maxillary sinus floor augmentation (MSFA) in the atrophic posterior maxilla?

Methodology: randomized split-mouth trial in 9 patients undergoing bilateral MSFA, with ADDM grafted on one side and xenograft on the other. Cone-beam CT assessed bone height and density at baseline and 6 months; core biopsies were taken for histologic analysis.

Findings: both grafts produced significant gains in bone height and density (p<0.001), with no significant difference between ADDM and xenograft in density gain (618.65 vs 540.87 HU, p=0.49) or height gain (9.34 vs 9.12 mm, p=0.724). Histology showed viable new bone in both groups, with ADDM showing higher collagen fiber density and vascularization.

Clinical relevance: in this small but well-controlled split-mouth design, donor-derived demineralized dentin matrix performed comparably to xenograft for sinus floor augmentation — a candidate alternative where xenogenic material is not preferred by the patient or clinician. The sample size (n=9) is small, so results should be confirmed in larger trials before changing standard practice.

Why it matters in practice

In this small split-mouth trial, allogenic demineralized dentin matrix produced bone height and density gains statistically indistinguishable from xenograft in sinus floor augmentation, with histology showing viable, well-vascularized new bone — a candidate alternative where xenogenic material is not preferred.

This summary is automatically generated from the original abstract and curated by Dr. Ernesto Bruschi. Always refer to the original publication for clinical decisions.
Read original article ↗View on PubMed ↗

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